Methylomic Biomarkers of Lithium Response in Bipolar Disorder: A Proof of Transferability Study.

ABSTRACT: Response to lithium (Li) is highly variable in bipolar disorders (BD) and no clinical or biological predictors of long-term response have been validated to date. Using a genome-wide methylomic approach (SeqCapEpi), we previously identified seven differentially methylated regions (DMRs) that discriminated good from non-responders (prophylactic response phenotype defined using the "Alda" scale). This study is a proof of transferability from bench to bedside of this epigenetic signature. For this purpose, we used Methylation Specific High-Resolution Melting (MS-HRM), a PCR based method that can be implemented in any medical laboratory at low cost and with minimal equipment. In 23 individuals with BD, MS-HRM measures of three out of seven DMRs were technically feasible and consistencies betwee

SUBMITTER: Marie-Claire C 

PROVIDER: S-EPMC8877131 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature