Effects of the NF-κB Signaling Pathway Inhibitor BAY11-7082 in the Replication of ASFV.

ABSTRACT: African swine fever virus (ASFV) mainly infects the monocyte/macrophage lineage of pigs and regulates the production of cytokines that influence host immune responses. Several studies have reported changes in cytokine production after infection with ASFV, but the regulatory mechanisms have not yet been elucidated. Therefore, the aim of this study was to examine the immune response mechanism of ASFV using transcriptomic and proteomic analyses. Through multi-omics joint analysis, it was found that ASFV infection regulates the expression of the host NF-B signal pathway and related cytokines. Additionally, changes in the NF-κB signaling pathway and IL-1β and IL-8 expression in porcine alveolar macrophages (PAMs) infected with ASFV were examined. Results show that ASFV infection activates the N

SUBMITTER: Gao Q 

PROVIDER: S-EPMC8877168 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature