Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears.

ABSTRACT: Loss of active synapses and alterations in membrane lipids are crucial events in physiological aging as well as in neurodegenerative disorders. Both are related to the abnormal aggregation of amyloid-beta (Aβ) species, generally known as amyloidosis. There are two major known human Aβ species: Aβ(1-40) and Aβ(1-42). However, which of these species have more influence on active synapses and membrane lipids is still poorly understood. Additionally, the time-dependent effect of Aβ species on alterations in membrane lipids of hippocampal neurones and glial cells remains unknown. Therefore, our study contributes to a better understanding of the role of Aβ species in the loss of active synapses and the dysregulation of membrane lipids in vitro. We showed that Aβ(1-40) or Aβ(1-42) treatment influ

SUBMITTER: Van Bulck M 

PROVIDER: S-EPMC8877175 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature