The Thermal Stability of the Collagen Triple Helix Is Tuned According to the Environmental Temperature.

ABSTRACT: Triple helix formation of procollagen occurs in the endoplasmic reticulum (ER) where the single-stranded α-chains of procollagen undergo extensive post-translational modifications. The modifications include prolyl 4- and 3-hydroxylations, lysyl hydroxylation, and following glycosylations. The modifications, especially prolyl 4-hydroxylation, enhance the thermal stability of the procollagen triple helix. Procollagen molecules are transported to the Golgi and secreted from the cell, after the triple helix is formed in the ER. In this study, we investigated the relationship between the thermal stability of the collagen triple helix and environmental temperature. We analyzed the number of collagen post-translational modifications and thermal melting temperature and α-chain composition of secre

SUBMITTER: Fujii KK 

PROVIDER: S-EPMC8877210 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature