Rapid SARS-CoV-2 Intra-Host and Within-Household Emergence of Novel Haplotypes.

ABSTRACT: In February 2020, the municipality of Vo', a small town near Padua (Italy) was quarantined due to the first coronavirus disease 19 (COVID-19)-related death detected in Italy. To investigate the viral prevalence and clinical features, the entire population was swab tested in two sequential surveys. Here we report the analysis of 87 viral genomes, which revealed that the unique ancestor haplotype introduced in Vo' belongs to lineage B, carrying the mutations G11083T and G26144T. The viral sequences allowed us to investigate the viral evolution while being transmitted within and across households and the effectiveness of the non-pharmaceutical interventions implemented in Vo'. We report, for the first time, evidence that novel viral haplotypes can naturally arise intra-host within an interval

SUBMITTER: Manuto L 

PROVIDER: S-EPMC8877413 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature