Preparation and Drug-Loading Properties of Amphoteric Cassava Starch Nanoparticles.

ABSTRACT: Based on the characteristics of charge reversal around the isoelectric point (pI) of amphoteric starch-containing anionic and cationic groups, amphoteric cassava starch nanoparticles (CA-CANPs) are prepared by a W/O microemulsion crosslinking method using (3-chloro-2-hydroxypropyl) trimethyl ammonium chloride as a cationic reagent and POCl3 as an anionic reagent, and the effects of preparation conditions on the particle size of the CA-CANPs are studied in detail in the present study. CA-CANPs with a smooth surface and an average diameter of 252 nm are successfully prepared at the following optimised conditions: a crosslinking agent amount of 15 wt%, an aqueous starch concentration of 6.0 wt%, an oil-water ratio of 10:1, a total surfactant amount of 0.20 g·mL-1, and a CHPTAC amount of 4.05

SUBMITTER: Xie X 

PROVIDER: S-EPMC8877468 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature