Manipulating Macrophage/Microglia Polarization to Treat Glioblastoma or Multiple Sclerosis.

ABSTRACT: Macrophages and microglia are implicated in several diseases with divergent roles in physiopathology. This discrepancy can be explained by their capacity to endorse different polarization states. Theoretical extremes of these states are called M1 and M2. M1 are pro-inflammatory, microbicidal, and cytotoxic whereas M2 are anti-inflammatory, immunoregulatory cells in favor of tumor progression. In pathological states, these polarizations are dysregulated, thus restoring phenotypes could be an interesting treatment approach against diseases. In this review, we will focus on compounds targeting macrophages and microglia polarization in two very distinctive pathologies: multiple sclerosis and glioblastoma. Multiple sclerosis is an inflammatory disease characterized by demyelination and axon deg

SUBMITTER: Kuntzel T 

PROVIDER: S-EPMC8877500 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature