3D Bioprinting of an In Vitro Model of a Biomimetic Urinary Bladder with a Contract-Release System.

ABSTRACT: The development of curative therapy for bladder dysfunction is usually hampered owing to the lack of reliable ex vivo human models that can mimic the complexity of the human bladder. To overcome this issue, 3D in vitro model systems offering unique opportunities to engineer realistic human tissues/organs have been developed. However, existing in vitro models still cannot entirely reflect the key structural and physiological characteristics of the native human bladder. In this study, we propose an in vitro model of the urinary bladder that can create 3D biomimetic tissue structures and dynamic microenvironments to replicate the smooth muscle functions of an actual human urinary bladder. In other words, the proposed biomimetic model system, developed using a 3D bioprinting approach, can recr

SUBMITTER: Chae S 

PROVIDER: S-EPMC8877589 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature