Differences between Arterial and Venous Umbilical Cord Plasma Metabolome and Association with Parity.

ABSTRACT: Umbilical cord blood is frequently used in health monitoring of the neonate. Results may be affected by the proportion of arterial and venous cord blood, the venous blood coming from the mother to supply oxygen and nutrients to the infant, and the arterial carrying waste products from the fetus. Here, we sampled arterial and venous umbilical cords separately from 48 newly delivered infants and examined plasma metabolomes using GC-MS/MS metabolomics. We investigated differences in metabolomes between arterial and venous blood and their associations with gestational length, birth weight, sex, and whether the baby was the first born or not, as well as maternal age and BMI. Using multilevel random forest analysis, a classification rate of 79% was achieved for arteriovenous differences (p = 0.0

SUBMITTER: Hartvigsson O 

PROVIDER: S-EPMC8877791 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature