SARS-CoV-2-Specific Vaccine Candidates; the Contribution of Structural Vaccinology.

ABSTRACT: SARS-CoV-2 vaccine production has taken us by storm. We aim to fill in the history of concepts and the work of pioneers and provide a framework of strategies employing structural vaccinology. Cryo-electron microscopy became crucial in providing three-dimensional (3D) structures and creating candidates eliciting T and B cell-mediated immunity. It also determined structural changes in the emerging mutants in order to design new constructs that can be easily, quickly and safely added to the vaccines. The full-length spike (S) protein, the S1 subunit and its receptor binding domain (RBD) of the virus are the best candidates. The vaccine development to cease this COVID-19 pandemic sets a milestone for the pan-coronavirus vaccine's designing and manufacturing. By employing structural vaccinology

SUBMITTER: Pack SM 

PROVIDER: S-EPMC8877865 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature