Surface presentation of the noncanonical Wnt5a motif to cytotoxic CD8⁺ T-cells promotes their mechanotransduction and activation.

ABSTRACT: We report here strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate to enhance the mechanotransduction and activation of cytotoxic CD8⁺ T cells by triggering the noncanonical Wnt signaling. This new mechanoregulatory ligand platform can be widely applied in the fundamental research of mechano-immunology and further the development of novel immunotherapies.

SUBMITTER: Li R 

PROVIDER: S-EPMC8877873 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature