Numerical Investigation on the Anti-Angiogenic Therapy-Induced Normalization in Solid Tumors.

ABSTRACT: This study numerically analyzes the fluid flow and solute transport in a solid tumor to comprehensively examine the consequence of normalization induced by anti-angiogenic therapy on drug delivery. The current study leads to a more accurate model in comparison to previous research, as it incorporates a non-homogeneous real-human solid tumor including necrotic, semi-necrotic, and well-vascularized regions. Additionally, the model considers the effects of concurrently chemotherapeutic agents (three macromolecules of IgG, F(ab')2, and F(ab')) and different normalization intensities in various tumor sizes. Examining the long-term influence of normalization on the quality of drug uptake by necrotic area is another contribution of the present study. Results show that normalization decreases the

SUBMITTER: Mohammadi M 

PROVIDER: S-EPMC8877966 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature