Genetic Variants of Interleukin-4 in Romanian Patients with Idiopathic Nephrotic Syndrome.

ABSTRACT: Background and objectives: One of the most frequent glomerular diseases in the pediatric population is represented by the idiopathic nephrotic syndrome (INS). The exact mechanisms mediating the disease are still unknown, but several genetic factors have been studied for possible implications. Cytokines are considered to play a pivotal role in mediating INS disease progression, interleukin-4 (IL-4) exhibiting particular interest. The objective of this research project was to investigate the association between two IL-4 gene single-nucleotide polymorphisms (SNPs) and INS susceptibility as well as response to steroid therapy, in a group of Romanian children. Materials and Methods: In total, 75 patients with INS and 160 healthy controls of Romanian origin were genotyped fo

SUBMITTER: Tieranu I 

PROVIDER: S-EPMC8877980 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature