Transmembrane serine protease 2 is a prognostic factor for lung adenocarcinoma.

ABSTRACT: Transmembrane serine protease 2 (TMPRSS2) has been intensively investigated during the current Sars‑CoV‑2 pandemic as a virus activating protease. Furthermore, TMPRSS2 is an oncogenic gene associated with several cancer entities. Co‑expression of TMPRSS2 and serpin family A member 1 (SERPINA1) (encoding alpha‑1‑antitrypsin; AAT) has been reported in the human lung. Recently, AAT was identified as a novel TMPRSS2 inhibitor. We previously reported that lower SERPINA1 expression in tumor tissues and higher levels of plasma AAT are associated with worse survival of patients with non‑small cell lung cancer (NSCLC). In the present study, we sought to examine TMPRSS2 and SERPINA1/AAT expression in tumor and adjacent lung tissues from 347 NSCLC patients. Based on clinic

SUBMITTER: Schneider MA 

PROVIDER: S-EPMC8878627 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature