Preliminary In Vitro Cytotoxicity, Mutagenicity and Antitumoral Activity Evaluation of Graphene Flake and Aqueous Graphene Paste.

ABSTRACT: This study aimed to determine the in vitro cytotoxicity and mutagenicity of graphene flake (GF) and aqueous graphene paste (AGP) in order to evaluate their potential for application as biomaterials. Furthermore, their antitumor activity against adherent and suspended cells, namely, human breast adenocarcinoma cells (MDA-MB-231), and human monocytes from histiocytic lymphoma (U-937), was investigated. The results demonstrated that GF reduced the viability and proliferation of NIH3T3 immortalized murine fibroblasts for concentrations >0.8 µg/mL and incubation times of 48 and 72 h. AGP showed no toxic effects in any of the tested concentrations and incubation times. The same results were obtained for MDA-MB-231 cells. The viability of the U-937 cells was not affected by either GF or AGP. The

SUBMITTER: Lamponi S 

PROVIDER: S-EPMC8878666 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature