Plant-Derived Recombinant Vaccines against Zoonotic Viruses.

ABSTRACT: Emerging and re-emerging zoonotic diseases cause serious illness with billions of cases, and millions of deaths. The most effective way to restrict the spread of zoonotic viruses among humans and animals and prevent disease is vaccination. Recombinant proteins produced in plants offer an alternative approach for the development of safe, effective, inexpensive candidate vaccines. Current strategies are focused on the production of highly immunogenic structural proteins, which mimic the organizations of the native virion but lack the viral genetic material. These include chimeric viral peptides, subunit virus proteins, and virus-like particles (VLPs). The latter, with their ability to self-assemble and thus resemble the form of virus particles, are gaining traction among plant-based candidat

SUBMITTER: Zahmanova G 

PROVIDER: S-EPMC8878793 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature