Mucosal Vaccines, Sterilizing Immunity, and the Future of SARS-CoV-2 Virulence.

ABSTRACT: Sterilizing immunity after vaccination is desirable to prevent the spread of infection from vaccinees, which can be especially dangerous in hospital settings while managing frail patients. Sterilizing immunity requires neutralizing antibodies at the site of infection, which for respiratory viruses such as SARS-CoV-2 implies the occurrence of neutralizing IgA in mucosal secretions. Systemic vaccination by intramuscular delivery induces no or low-titer neutralizing IgA against vaccine antigens. Mucosal priming or boosting, is needed to provide sterilizing immunity. On the other side of the coin, sterilizing immunity, by zeroing interhuman transmission, could confine SARS-CoV-2 in animal reservoirs, preventing spontaneous attenuation of virulence in humans as presumably happened with the ende

SUBMITTER: Focosi D 

PROVIDER: S-EPMC8878800 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature