Immunosuppressive Properties of Epidermal Keratinocytes Differ According to Their Immaturity Status.

ABSTRACT: Preservation of a functional keratinocyte stem cell pool is essential to ensure the long-term maintenance of epidermis integrity, through continuous physiological renewal and regeneration in case of injury. Protecting stem cells from inflammation and immune reactions is thus a critical issue that needs to be explored. Here, we show that the immature CD49f^high precursor cell fraction from interfollicular epidermis keratinocytes, comprising stem cells and progenitors, is able to inhibit CD4 ⁺ T-cell proliferation. Of note, both the stem cell-enriched CD49f^high/EGFR^low subpopulation and the less immature CD49f^high/EGFR^high progenitors ensure this effect. Moreover, we show that HLA-G and PD-L1 immune checkpoints are overe

SUBMITTER: Mestrallet G 

PROVIDER: S-EPMC8878806 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature