Identification of a new RNA-binding proteins-based signature for prognostic prediction in gastric cancer.

ABSTRACT:

Abstract

Gastric cancer (GC) is one of the most common cancers with high incidence and mortality worldwide. Recently, RNA-binding proteins (RBPs) have drawn more and more attention for its role in cancer pathophysiology. However, the function and clinical implication of RBPs in GC have not been fully elucidated. RNA sequencing data along with the corresponding clinical information of GC patients were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed RNA-binding proteins (DERBPs) between tumor and normal tissues were identified by "limma" package. Functional enrichment analysis and the protein-protein interaction (PPI) network were harnessed to explore the function and interaction of DERBPs. Next, univariate and multiple Cox regression were applied to

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8878810 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature