Genome Characterization and Probiotic Potential of Corynebacterium amycolatum Human Vaginal Isolates.

ABSTRACT: The vaginal microbiome of healthy women contains nondiphtheria corynebacteria. The role and functions of nondiphtheria corynebacteria in the vaginal biotope are still under study. We sequenced and analysed the genomes of three vaginal C. amycolatum strains isolated from healthy women. Previous studies have shown that these strains produced metabolites that significantly increased the antagonistic activity of peroxide-producing lactic acid bacteria against pathogenic and opportunistic microorganisms and had strong antimicrobial activity against opportunistic pathogens. Analysis of the C. amycolatum genomes revealed the genes responsible for adaptation and survival in the vaginal environment, including acid and oxidative stress resistance genes. The genes responsible for the production of H2

SUBMITTER: Gladysheva IV 

PROVIDER: S-EPMC8878833 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature