Salmon Erythrocytes Sequester Active Virus Particles in Infectious Salmon Anaemia.

ABSTRACT: Infectious salmon anaemia virus (ISAV) binds circulating Atlantic salmon erythrocytes, but the relevance of this interaction for the course of infection and development of disease remains unclear. We here characterise ISAV-erythrocyte interactions in experimentally infected Atlantic salmon and show that ISAV-binding to erythrocytes is common and precedes the development of disease. Viral RNA and infective particles were enriched in the cellular fraction of blood. While erythrocyte-associated ISAV remained infectious, erythrocytes dose-dependently limited the infection of cultured cells. Surprisingly, immunostaining of blood smears revealed expression of ISAV proteins in a small fraction of erythrocytes in one of the examined trials, confirming that ISAV can be internalised in this cell typ

SUBMITTER: Fosse JH 

PROVIDER: S-EPMC8879071 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature