Lyotropic Liquid Crystals: A Biocompatible and Safe Material for Local Cardiac Application.

ABSTRACT: The regeneration of cardiac tissue is a multidisciplinary research field aiming to improve the health condition of the post-heart attack patient. Indeed, myocardial tissue has a poor ability to self-regenerate after severe damage. The scientific efforts focused on the research of a biomaterial able to adapt to heart tissue, thus guaranteeing the in situ release of active substances or growth promoters. Many types of hydrogels were proposed for this purpose, showing several limitations. The aim of this study was to suggest a new usage for glyceryl monooleate-based lyotropic liquid crystals (LLCs) as a biocompatible and inert material for a myocardial application. The main advantages of LLCs are mainly related to their easy in situ injection as lamellar phase and their instant in situ transi

SUBMITTER: Mancuso A 

PROVIDER: S-EPMC8879243 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature