Nanoparticles Surface Chemistry Influence on Protein Corona Composition and Inflammatory Responses.

ABSTRACT: Nanoparticles are widely used for biomedical applications such as vaccine, drug delivery, diagnostics, and therapeutics. This study aims to reveal the influence of nanoparticle surface functionalization on protein corona formation from blood serum and plasma and the subsequent effects on the innate immune cellular responses. To achieve this goal, the surface chemistry of silica nanoparticles of 20 nm diameter was tailored via plasma polymerization with amine, carboxylic acid, oxazolines, and alkane functionalities. The results of this study show significant surface chemistry-induced differences in protein corona composition, which reflect in the subsequent inflammatory consequences. Nanoparticles rich with carboxylic acid surface functionalities increased the production of pro-inflammatory

SUBMITTER: Gonzalez-Garcia LE 

PROVIDER: S-EPMC8879273 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature