Rationalisation of Antifungal Properties of α-Helical Pore-Forming Peptide, Mastoparan B.

ABSTRACT: The high mortality associated with invasive fungal infections, narrow spectrum of available antifungals, and increasing evolution of antifungal resistance necessitate the development of alternative therapies. Host defense peptides are regarded as the first line of defense against microbial invasion in both vertebrates and invertebrates. In this work, we investigated the effectiveness of four naturally occurring pore-forming antimicrobial peptides (melittin, magainin 2, cecropin A, and mastoparan B) against a panel of clinically relevant pathogens, including Candida albicans, Candida parapsilosis, Candida tropicalis, and Candida glabrata. We present data on the antifungal activities of the four pore-forming peptides, assessed with descriptive statistics, and their cytocompatibility with cul

SUBMITTER: Lim EJ 

PROVIDER: S-EPMC8879275 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature