Genomic Bootstrap Barcodes and Their Application to Study the Evolution of Sarbecoviruses.

ABSTRACT: Recombination creates mosaic genomes containing regions with mixed ancestry, and the accumulation of such events over time can complicate greatly many aspects of evolutionary inference. Here, we developed a sliding window bootstrap (SWB) method to generate genomic bootstrap (GB) barcodes to highlight the regions supporting phylogenetic relationships. The method was applied to an alignment of 56 sarbecoviruses, including SARS-CoV and SARS-CoV-2, responsible for the SARS epidemic and COVID-19 pandemic, respectively. The SWB analyses were also used to construct a consensus tree showing the most reliable relationships and better interpret hidden phylogenetic signals. Our results revealed that most relationships were supported by just a few genomic regions and confirmed that three divergent lin

SUBMITTER: Hassanin A 

PROVIDER: S-EPMC8879460 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature