SARS-CoV-2: Ultrastructural Characterization of Morphogenesis in an In Vitro System.

ABSTRACT: The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impacted public health and the world economy and fueled a worldwide race to approve therapeutic and prophylactic agents, but so far there are no specific antiviral drugs. Understanding the biology of the virus is the first step in structuring strategies to combat it, and in this context several studies have been conducted with the aim of understanding the replication mechanism of SARS-CoV-2 in vitro systems. In this work, studies using transmission and scanning electron microscopy and 3D electron microscopy modeling were performed with the goal of characterizing the morphogenesis of SARS-CoV-2 in Vero-E6 cells. Several ultrastructural changes were observed-such as syncytia formation, cytoplasmic mem

SUBMITTER: Barreto-Vieira DF 

PROVIDER: S-EPMC8879486 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature