Evolution of TRIM5 and TRIM22 in Bats Reveals a Complex Duplication Process.

ABSTRACT: The innate immunological response in mammals involves a diverse and complex network of many proteins. Over the last years, the tripartite motif-containing protein 5 (TRIM5) and 22 (TRIM22) have shown promise as restriction factors of a plethora of viruses that infect primates. Although there have been studies describing the evolution of these proteins in a wide range of mammals, no prior studies of the TRIM6/34/5/22 gene cluster have been performed in the Chiroptera order. Here, we provide a detailed analysis of the evolution of this gene cluster in several bat genomes. Examination of different yangochiroptera and yinpterochiroptera bat species revealed a dynamic history of gene expansion occurring in TRIM5 and TRIM22 genes. Multiple copies of T

SUBMITTER: Fernandes AP 

PROVIDER: S-EPMC8879501 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature