Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation.

ABSTRACT:

Background

Largely due to incidental detection, asymptomatic pancreatic cystic lesions (PCLs) have become prevalent in recent years. Among them, intraductal papillary mucinous neoplasm (IPMN) infrequently advances to pancreatic ductal adenocarcinoma (PDAC). Conservative surveillance versus surgical intervention is a difficult clinical decision for both caregivers and PCL patients. Because RNF43 loss-of-function mutations and KRAS gain-of-function mutations concur in a subset of IPMN and PDAC, their biological significance and therapeutic potential should be elucidated.

Methods

Pancreatic Rnf43 knockout and Kras activated mice (Rnf43^-/-; Kras^G12D) were generated to evaluate their clinical significance in pancreatic pre-neoplastic initiation and malignant

SUBMITTER: Zhou X 

PROVIDER: S-EPMC8879633 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature