Comparative Genomics of Clostridium baratii Reveals Strain-Level Diversity in Toxin Abundance.

ABSTRACT: Clostridium baratii strains are rare opportunistic pathogens associated with botulism intoxication. They have been isolated from foods, soil and be carried asymptomatically or cause botulism outbreaks. Is not taxonomically related to Clostridium botulinum, but some strains are equipped with BoNT/F7 cluster. Despite their relationship with diseases, our knowledge regarding the genomic features and phylogenetic characteristics is limited. We analyzed the pangenome of C. baratii to understand the diversity and genomic features of this species. We compared existing genomes in public databases, metagenomes, and one newly sequenced strain isolated from an asymptomatic subject. The pangenome was open, indicating it comprises genetically diverse organisms. The core genome cont

SUBMITTER: Silva-Andrade C 

PROVIDER: S-EPMC8879937 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature