Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.

ABSTRACT: Exosomes, key mediators of cell-cell communication, derived from type 2 diabetes mellitus (T2DM) exhibit detrimental effects. Exercise improves endothelial function in part via the secretion of exosomes into circulation. Extracellular superoxide dismutase (SOD3) is a major secretory copper (Cu) antioxidant enzyme that catalyzes the dismutation of O₂ ^•- to H₂ O₂ whose activity requires the Cu transporter ATP7A. However, the role of SOD3 in exercise-induced angiogenic effects of circulating plasma exosomes on endothelial cells (ECs) in T2DM remains unknown. Here, we show that both SOD3 and ATP7A proteins were present in plasma exosomes in mice, which was significantly increased after two weeks of volunteer wheel exercise. A single bout of exercise

SUBMITTER: Abdelsaid K 

PROVIDER: S-EPMC8880294 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature