Discovery of Novel Andrographolide Derivatives as Antiviral Inhibitors against Human Enterovirus A71.

ABSTRACT: Hand-foot-and-mouth disease (HFMD) caused by human enterovirus A71 (EV-A71) infection has been associated with severe neurological complications. With the lack of an internationally approved antiviral, coupled with a surge in outbreaks globally, EV-A71 has emerged as a neurotropic virus of high clinical importance. Andrographolide has many pharmacological effects including antiviral activity and its derivative, andrographolide sulfonate, has been used in China clinically to treat EV-A71 infections. This study sought to identify novel andrographolide derivatives as EV-A71 inhibitors and elucidate their antiviral mode of action. Using an immunofluorescence-based phenotypic screen, we identified novel EV-A71 inhibitors from a 344-compound library of andrographolide derivatives and validated t

SUBMITTER: Tan JK 

PROVIDER: S-EPMC8880313 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature