Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells.

ABSTRACT: Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects, mostly, the elder population, with a high mortality rate (>80%) upon rupture. It features a dilation of the aortic diameter to larger than 30 mm or more than 50%. Diverse pathological processes are involved in the development of AAA, including aortic wall inflammation, elastin breakdown, oxidative stress, smooth muscle cell (SMC) phenotypic switching and dysfunction, and extracellular matrix degradation. With open surgery being the only therapeutic option up to date, the lack of pharmaceutical treatment approach calls for identifying novel and effective targets and further understanding the pathological process of AAA. Both lifestyle and genetic predisposition have an important role in increasing the ri

SUBMITTER: Qian G 

PROVIDER: S-EPMC8880357 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature