Piperlongumine as a Neuro-Protectant in Chemotherapy Induced Cognitive Impairment.

ABSTRACT: Advances in the early diagnosis and treatment have led to increases in breast cancer survivorship. Survivors report cognitive impairment symptoms such as loss of concentration and learning and memory deficits which significantly reduce the patient's quality of life. Additional therapies are needed to prevent these side effects and, the precise mechanisms of action responsible are not fully elucidated. However, increasing evidence points toward the use of neuroprotective compounds with antioxidants and anti-inflammatory properties as tools for conserving learning and memory. Here, we examine the ability of piperlongumine (PL), an alkaloid known to have anti-inflammatory and antioxidant effects, to play a neuroprotective role in 16-week-old female C57BL/6J mice treated with a common breast c

SUBMITTER: Ntagwabira F 

PROVIDER: S-EPMC8880369 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature