Overcoming Radiation Resistance in Gliomas by Targeting Metabolism and DNA Repair Pathways.

ABSTRACT: Gliomas represent a wide spectrum of brain tumors characterized by their high invasiveness, resistance to chemoradiotherapy, and both intratumoral and intertumoral heterogeneity. Recent advances in transomics studies revealed that enormous abnormalities exist in different biological layers of glioma cells, which include genetic/epigenetic alterations, RNA expressions, protein expression/modifications, and metabolic pathways, which provide opportunities for development of novel targeted therapeutic agents for gliomas. Metabolic reprogramming is one of the hallmarks of cancer cells, as well as one of the oldest fields in cancer biology research. Altered cancer cell metabolism not only provides energy and metabolites to support tumor growth, but also mediates the resistance of tumor cells to

SUBMITTER: Meng W 

PROVIDER: S-EPMC8880405 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature