In Vitro and In Silico Antimalarial Evaluation of FM-AZ, a New Artemisinin Derivative.

ABSTRACT: Artemisinin-based Combination Therapies (ACTs) are currently the frontline treatment against Plasmodium falciparum malaria, but parasite resistance to artemisinin (ART) and its derivatives, core components of ACTs, is spreading in the Mekong countries. In this study, we report the synthesis of several novel artemisinin derivatives and evaluate their in vitro and in silico capacity to counteract Plasmodium falciparum artemisinin resistance. Furthermore, recognizing that the malaria parasite devotes considerable resources to minimizing the oxidative stress that it creates during its rapid consumption of hemoglobin and the release of heme, we sought to explore whether further augmentation of this oxidative toxicity might constitute an important addition to artemisinins. The present repor

SUBMITTER: Tsamesidis I 

PROVIDER: S-EPMC8880451 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature