Fifty Shades of E^rns: Innate Immune Evasion by the Viral Endonucleases of All Pestivirus Species.

ABSTRACT: The genus Pestivirus, family Flaviviridae, includes four historically accepted species, i.e., bovine viral diarrhea virus (BVDV)-1 and -2, classical swine fever virus (CSFV), and border disease virus (BDV). A large number of new pestivirus species were identified in recent years. A common feature of most members is the presence of two unique proteins, N^pro and E^rns, that pestiviruses evolved to regulate the host's innate immune response. In addition to its function as a structural envelope glycoprotein, E^rns is also released in the extracellular space, where it is endocytosed by neighboring cells. As an endoribonuclease, E^rns is able to cleave viral ss- and dsRNAs, thus preventing the stimulation of the host's interferon (IFN) respo

SUBMITTER: de Martin E 

PROVIDER: S-EPMC8880635 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature