Computational modelling of cell motility modes emerging from cell-matrix adhesion dynamics.

ABSTRACT: Lymphocytes have been described to perform different motility patterns such as Brownian random walks, persistent random walks, and Lévy walks. Depending on the conditions, such as confinement or the distribution of target cells, either Brownian or Lévy walks lead to more efficient interaction with the targets. The diversity of these motility patterns may be explained by an adaptive response to the surrounding extracellular matrix (ECM). Indeed, depending on the ECM composition, lymphocytes either display a floating motility without attaching to the ECM, or sliding and stepping motility with respectively continuous or discontinuous attachment to the ECM, or pivoting behaviour with sustained attachment to the ECM. Moreover, on the long term, lymphocytes either perform a persistent random wal

SUBMITTER: van Steijn L 

PROVIDER: S-EPMC8880896 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature