Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish.

ABSTRACT: Aging individuals exhibit a pervasive decline in adaptive immune function, with important implications for health and lifespan. Previous studies have found a pervasive loss of immune-repertoire diversity in human peripheral blood during aging; however, little is known about repertoire aging in other immune compartments, or in species other than humans. Here, we perform the first study of immune-repertoire aging in an emerging model of vertebrate aging, the African turquoise killifish (Nothobranchius furzeri). Despite their extremely short lifespans, these killifish exhibit complex and individualized heavy-chain repertoires, with a generative process capable of producing millions of distinct productive sequences. Whole-body killifish repertoires decline rapidly in within-individual d

SUBMITTER: Bradshaw WJ 

PROVIDER: S-EPMC8880994 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature