Comparative vaccine effectiveness against severe COVID-19 over time in US hospital administrative data: a case-control study.

ABSTRACT:

Background

Research suggests the protection offered by COVID-19 vaccines might wane over time, prompting consideration of booster vaccinations. Data on which vaccines offer the most robust protection over time, and which patients are most vulnerable to attenuating protection, could help inform potential booster programmes. In this study, we used comprehensive hospitalisation data to estimate vaccine effectiveness over time.

Methods

In this case-control study, we used data from a large US health-care system to estimate vaccine effectiveness against severe SARS-CoV-2 infection and examined variation based on time since vaccination, vaccine type, and patients' demographic and clinical characteristics. We compared trends in attenuation of protection across vaccines and used a mu

SUBMITTER: Wright BJ 

PROVIDER: S-EPMC8881000 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature