Protein Aggregation Nucleated by Functionalized Dendritic Polyglycerols.

ABSTRACT: Dendritic polyglycerols (dPGs) are emerging as important polymers for the study of biological processes due to their relatively low toxicity and excellent biocompatibility. The highly branched nature and high density of endgroups make the dPGs particularly attractive frameworks for the study of multivalent interactions such as multivalent protein-carbohydrate interactions. Here, we report the synthesis of a series of lactose functionalized dPGs with different hydrodynamic radii. A series of lactose functionalized dPGs bearing different densities of lactose functional groups was also synthesized. These lactose functionalized dPGs were used to study the templated aggregation of galectin-3, a galactoside binding protein that is overexpressed during many processes involved in cancer progressio

SUBMITTER: Bernhard SP 

PROVIDER: S-EPMC8881006 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature