Pharmacotherapies for cannabis use disorder: A systematic review and network meta-analysis.

ABSTRACT:

Objective

This study aimed to determine the efficacy and acceptability of pharmacotherapies for cannabis use disorder (CUD).

Methods

We conducted a systematic review and frequentist network meta-analysis, searching five electronic databases for randomized placebo-controlled trials of individuals diagnosed with CUD receiving pharmacotherapy with or without concomitant psychotherapy. Primary outcomes were the reduction in cannabis use and retention in treatment. Secondary outcomes were adverse events, discontinuation due to adverse events, total abstinence, withdrawal symptoms, cravings, and CUD severity. We applied a frequentist, random-effects Network Meta-Analysis model to pool effect sizes across trials using standardized mean differences (SMD, g) and rate ratios (RR) with

SUBMITTER: Bahji A 

PROVIDER: S-EPMC8881089 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature