Protracted abstinence in males with an opioid use disorder: partial recovery of nucleus accumbens function.

ABSTRACT: Opioid use disorder (OUD) affects more than 27 million people globally accounting for more than 300,000 deaths annually. Protracted abstinence among individuals with OUD is rare due to a high relapse rate among those not receiving medications for OUD. Extensive preclinical studies form the basis of the allostasis theory, which proposes long-lasting functional brain abnormalities that persist after opioid withdrawal and contribute to relapse. Few studies have tested the allostasis theory in humans using neuroimaging. Here, we used fMRI and an instrumental learning task to test allostasis theory predictions (ATP) of functional abnormalities in both positive valence (PVS) and negative valence (NVS) accumbens systems in OUD patients with protracted abstinence (n = 15), comparing them with OUD

SUBMITTER: Tolomeo S 

PROVIDER: S-EPMC8881207 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature