Targeting abundant survivin expression in liposarcoma: subtype dependent therapy responses to YM155 treatment.

ABSTRACT:

Purpose

Liposarcoma (LPS) represent the largest group of malignant soft tissue tumours comprising a heterogeneous group of subtypes in which the degrees of chemoresistance and radiosensitivity strongly vary. Consequently, it is of utmost interest to establish novel therapeutic regimens based on molecular targets.

Methods

Immunohistochemical staining of survivin was performed in tissue microarrays comprising 49 primary LPS specimens. LPS cell lines were treated with survivin antagonist YM155 and doxorubicin or etoposide alone as well as in combination. Changes in cell viability were investigated and the synergistic effect of a combined therapy analysed.

Results

Immunohistochemistry revealed an abundant expression of survivin in LPS that significantly concurred with les

SUBMITTER: Vay C 

PROVIDER: S-EPMC8881260 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature