Fetal lipidome and incident risk of food allergy: A prospective birth cohort study.

ABSTRACT:

Background

Lipids are proposed to be important in developing adaptive immunity and allergy. However, studies to date reported inconsistent findings.

Objective

To examine newborn lipidome (a comprehensive profiling of circulating lipid metabolites) on child's risk of developing food allergy (FA). The maternal-cord joint effects of lipid metabolites on FA development were also investigated.

Methods

This study included 647 mother-child pairs from the Boston Birth Cohort and analyzed 202 lipid metabolites in cord plasma profiled by liquid chromatography tandem mass spectrometry. FA was defined based on standard clinical criteria. Logistic regression was applied to examine the relationships between individual metabolites and risk of FA.

Results

Of the 647 children,

SUBMITTER: Hong X 

PROVIDER: S-EPMC8881306 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature