Circulating T Cells Are Not Sufficient for Protective Immunity against Virulent Francisella tularensis.

ABSTRACT: Pulmonary infections elicit a combination of tissue-resident and circulating T cell responses. Understanding the contribution of these anatomically distinct cellular pools in protective immune responses is critical for vaccine development. Francisella tularensis is a highly virulent bacterium capable of causing lethal systemic disease following pulmonary infection for which there is no currently licensed vaccine. Although T cells are required for survival of F. tularensis infection, the relative contribution of tissue-resident and circulating T cells is not completely understood, hampering design of effective, long-lasting vaccines directed against this bacterium. We have previously shown that resident T cells were not sufficient to protect against F. tularensis, sugge

SUBMITTER: Roberts LM 

PROVIDER: S-EPMC8881340 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature