Contributions of chronic tobacco smoking to HIV-associated brain atrophy and cognitive deficits.

ABSTRACT:

Objectives

Tobacco smoking is linked to cognitive deficits and greater white matter (WM) abnormalities in people with HIV disease (PWH). Whether tobacco smoking additionally contributes to brain atrophy in PWH is unknown and was evaluated in this study.

Design

We used a 2 × 2 design that included 83 PWH (43 nonsmokers, 40 smokers) and 171 HIV-seronegative (SN, 106 nonsmokers, 65 smokers) participants and assessed their brain structure and cognitive function.

Methods

Selected subcortical volumes, voxel-wise cortical volumes and thickness, and total WM volume were analyzed using FreeSurfer. Independent and interactive effects of HIV and smoking were evaluated with two-way analysis of covariance on cognitive domain Z-scores and morphometric measures on T1-weighted MRI.

SUBMITTER: Liang HJ 

PROVIDER: S-EPMC8881356 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature