Contribution of Dendritic Cell Subsets to T Cell-Dependent Responses in Mice.

ABSTRACT: BATF3-deficient mice that lack CD8⁺ dendritic cells (DCs) showed an exacerbation of chronic graft-versus-host disease (cGVHD), including T follicular helper (Tfh) cell and autoantibody responses, whereas mice carrying the Sle2c2 lupus-suppressive locus with a mutation in the G-CSFR showed an expansion of CD8⁺ DCs and a poor mobilization of plasmacytoid DCs (pDCs) and responded poorly to cGVHD induction. Here, we investigated the contribution of CD8⁺ DCs and pDCs to the humoral response to protein immunization, where CD8^neg DCs are thought to represent the major inducers. Both BATF3^-/- and Sle2c2 mice had reduced humoral and germinal center (GC) responses compared with C57BL/6 (B6) controls. We showed that B6-derived CD4

SUBMITTER: Abboud G 

PROVIDER: S-EPMC8881363 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature