Cough desensitization treatment: A randomized, sham-controlled pilot trial for patients with refractory chronic cough.

ABSTRACT:

Background

The purpose of this study was to determine feasibility of treating refractory chronic cough (RCC) with progressive doses of capsaicin paired with cough suppression.

Methods

In this sham-controlled, parallel RCT, 14 adults with RCC were randomly assigned to either behavioral cough suppression therapy (BCST) plus 6 treatment sessions involving exposure to nebulized capsaicin in progressively larger concentrations while actively suppressing cough (n = 8), or BCST plus 6 sessions of exposure to a single subthreshold dose of capsaicin (sham; n = 6). The Leicester Cough Questionnaire (LCQ) was the primary outcome measure. Urge-to-cough (UTC) testing, measuring both UTC and cough frequency, served as secondary outcome measures. Data was analyzed with mixed effects linear

SUBMITTER: Slovarp L 

PROVIDER: S-EPMC8881373 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature