Estimates of minimal clinically important improvments vary with the responsiveness of the sample.

ABSTRACT:

Objective

Minimal clinically important improvements (MCII) are known to vary with the baseline level in the sample. We examined if MCIIs are also larger in samples with higher responsiveness.

Study design and setting

In a prospective longitudinal study of patients with active rheumatoid arthritis, we assessed arthritis activity before and after new treatments. We estimated anchor-based MCIIs for three outcomes (pain severity, physical functioning by the Health Assessment Questionnaire, and Simplified Disease Activity Index, a composite measure) using receiver operating characteristic curves. We compared MCIIs among patients treated with three interventions of different impact (dose escalation, new disease-modifying medication, or prednisone). Separately, we used simulations

SUBMITTER: Ward MM 

PROVIDER: S-EPMC8881395 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature