Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.

ABSTRACT: The formylpeptide receptors (FPRs) mediate pattern recognition of formylated peptides derived from invading pathogens or mitochondria from dead host cells. They can also sense other structurally distinct native peptides and even lipid mediators to either promote or resolve inflammation. Pharmacological targeting of FPRs represents a novel therapeutic approach in treating inflammatory diseases. However, the molecular mechanisms underlying FPR ligand recognition are elusive. We report cryo-EM structures of G_i-coupled FPR1 and FPR2 bound to a formylpeptide and G_i-coupled FPR2 bound to two synthetic peptide and small-molecule agonists. Together with mutagenesis data, our structures reveal the molecular mechanism of formylpeptide recognition by FPRs and structural variatio

SUBMITTER: Zhuang Y 

PROVIDER: S-EPMC8881469 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature